One company was formed early in 2018 when a group of hospitals—fed up with drug shortages and price spikes—promised to upend the market.

Another raised $45 million to support its quest to transform surgery using artificial intelligence, while yet another is trying to reinvent community cancer care.

This is just a taste of the inaugural class of FierceHealthcare’s Fierce 15 honorees.

In total, this year’s 15 companies saw more than $700 million in funding rounds and capital commitments. But beyond that, each brought a passion for using their unique solution to truly impact patients.

Big and small, high-tech and not, we’re honoring this collection of companies across the U.S. that are trying to change the world by changing the healthcare industry.

Check out our inaugural class of the Fierce 15 Healthcare winners below and get inspired.